Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0892920200290050376
Experimental Neurobiology
2020 Volume.29 No. 5 p.376 ~ p.388
Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson¡¯s Disease
Seo Jin-Cheol

Won Jin-Young
Kim Keon-Woo
Park Jung-Hyung
Yeo Hyeon-Gu
Kim Yu-Gyeong
Baek Seung-Ho
Lee Hoon-Won
Jeon Chang-Yeop
Choi Won-Seok
Lee Sang-Il
Kim Ki-Jin
Park Sung-Hyun
Son Yeong-Hoon
Jeong Kang-Jin
Lim Kyung-Seob
Kang Phil-Yong
Lee Hwal-Yong
Son Hee-Chang
Huh Jae-Won
Kim Young-Hyun
Lee Dong-Seok
Lee Sang-Rae
Choi Ji-Woong
Lee Young-Jeon
Abstract
Symptoms of Parkinson¡¯s disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an essential role in the analysis of PD pathophysiology and behavior symptoms. As impairments of hand dexterity function can affect activities of daily living in patients with PD, research on hand dexterity function in NHP models with chronic PD is essential. Traditional rating scales previously used in the evaluation of animal spontaneous behavior were insufficient due to factors related to subjectivity and passivity. Thus, experimentally designed applications for an appropriate apparatus are necessary. In this study, we aimed to longitudinally assess hand dexterity function using hand dexterity task (HDT) in NHP-PD models. To validate this assessment, we analyzed the alteration in Parkinsonian tremor signs and the functionality of presynaptic dopaminergic neuron using positron emission tomography imaging of dopamine transporters in these models. In addition, a significant inverse correlation between HDT and DAT level was identified, but no local bias was found. The correlation with intention tremor signs was lower than the resting tremor. In conclusion, the evaluation of HDT may reflect behavioral symptoms of NHP-PD models. Furthermore, HDT was effectively used to experimentally distinguish intention tremors from other tremors.
KEYWORD
Parkinson's disease, Non-human primate, Hand dexterity function, Hand dexterity task, Tremor
FullTexts / Linksout information
Listed journal information
SCI(E) ÇмúÁøÈïÀç´Ü(KCI) KoreaMed